Volume No. 12 Issue No.: 3 Page No.: 277-284 January-March 2018




Sharma Richa 1 and Gupta Mahendra K.*2

1. School of Studies in Microbiology, Jiwaji University, Gwalior, Madhya Pradesh (INDIA) 2. School of Studies in Botany, Jiwaji University, Gwalior, Madhya Pradesh (INDIA)


Received on : September 28, 2017




There are large number of poisonous substances generated during several industrial processes and accumulate in soil, air and water, in which heavy metals are one of them. Heavy metals are non-biodegradable and have tendency to accumulate in food chain. Heavy metals are harmful for animal, plants, microbes as well as for human beings. Although some are required as trace element for various metabolic activities. Harmful effects of these heavy metals in humans are due to their ability to disturb the function of biological molecules such as protein, enzyme and DNA. Ingestion of heavy metals contaminated food and water in human beings leading to severe disease related to gastrointestinal disorders. These heavy metals are also show adverse effects on gut micro flora results in the disturbance of intestinal homeostasis. Lactic acid bacteria most frequently used as probiotic have the ability to bind and sequester metals that enter in the body. In addition, multiple potential beneficial effects have been attributed to the use of probiotic bacteria include improvement in lactose intolerance and intestinal disorder, antagonism against various pathogenic organisms, antimutagenic and anticarcinogenic action etc. Thus, our aim of study is to isolate heavy metals resistant strains of lactic acid bacteria from different sources. These heavy metals resistance probiotic strains of LAB could be applied as efficient probiotics for in vivo use by human where they solve the problem of heavy metals contamination and bioaccumulations.


Keywords : Heavy metals, Lactic acid bacteria, Probiotic, Bioaccumulation, Gut micro flora, Human effect